Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

Chiara Zuccato, Andrea Ciammola, Dorotea Rigamonti, +10

Science

Neurodegenerative DiseasesWild-type Huntingtin ActivityBdnf ProductionGeneticsWild-type Huntingtin +10

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

Chiara Zuccato, Marzia Tartari, Andrea Crotti, +9

Nature Genetics

Systems BiologySignal TransductionMolecular NeuroscienceDevelopmental BiologyMolecular Physiology +8

A microRNA-based gene dysregulation pathway in Huntington's disease

Rory Johnson, Chiara Zuccato, Nikolai D. Belyaev, +3

Neurobiology of Disease

GeneticsSmall RnaNeurodegenerationMicrorna DetectionMedicine +2

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

Andrea Crotti, Christopher Benner, Bilal E. Kerman, +7

Nature Neuroscience

InflammationCytokineMolecular NeuroscienceImmune Cell DevelopmentMedicine +10

Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease

Marta Valenza, Dorotea Rigamonti, Donato Goffredo, +16

Journal of Neuroscience

Widespread Disruption of Repressor Element-1 Silencing Transcription Factor/Neuron-Restrictive Silencer Factor Occupancy at Its Target Genes in Huntington's Disease

Chiara Zuccato, Nikolai N. Belyaev, Paola Conforti, +8

Journal of Neuroscience

RESEARCH ARTICLE: Systematic Assessment of BDNF and Its Receptor Levels in Human Cortices Affected by Huntington's Disease

Chiara Zuccato, Manuela Marullo, Paola Conforti, +3

Brain Pathology

Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery

Chiara Zuccato, Daniel Liber, Catarina Ramos, +5

Pharmacological Research

Progressive LossBdnf DeliveryPathologyDegenerative DiseaseDegenerative Pathology +7

Calcium Homeostasis and Mitochondrial Dysfunction in Striatal Neurons of Huntington Disease

Dmitry Lim, Laura Fedrizzi, Marzia Tartari, +4

Journal of Biological Chemistry

Ca2+ HomeostasisMitochondrial DysfunctionCellular PhysiologyOxidative StressCa2+ Stress +16

The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

Stefano Camnasio, Alessia Delli Carri, Angelo Lombardo, +19

Neurobiology of Disease

Genome InstabilityHeterozygous HuntingtonInduced Pluripotent Stem CellGenetic DisorderMedicine +10