Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

Chiara Zuccato, Andrea Ciammola, Dorotea Rigamonti, +10

Science

Neurodegenerative DiseasesWild-type Huntingtin ActivityBdnf ProductionGeneticsWild-type Huntingtin +10

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

Chiara Zuccato, Marzia Tartari, Andrea Crotti, +9

Nature Genetics

Systems BiologySignal TransductionMolecular NeuroscienceDevelopmental BiologyMolecular Physiology +8

Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease

Marta Valenza, Dorotea Rigamonti, Donato Goffredo, +16

Journal of Neuroscience

Adherent Neural Stem (NS) Cells from Fetal and Adult Forebrain

Steven M. Pollard, Luciano Conti, Yirui Sun, +2

Cerebral Cortex

Adult Stem CellCerebral OrganoidAdherent Neural StemRegenerative MedicineNeuroregeneration +16

Huntingtin's Neuroprotective Activity Occurs via Inhibition of Procaspase-9 Processing

Dorotea Rigamonti, Simonetta Sipione, Donato Goffredo, +3

Journal of Biological Chemistry

Calcium-dependent Cleavage of Endogenous Wild-type Huntingtin in Primary Cortical Neurons

Donato Goffredo, Dorotea Rigamonti, Marzia Tartari, +5

Journal of Biological Chemistry

An optimized experimental strategy for efficient conversion of embryonic stem (ES)-derived mouse neural stem (NS) cells into a nearly homogeneous mature neuronal population

Dimitrios Spiliotopoulos, Donato Goffredo, Luciano Conti, +4

Neurobiology of Disease

Regenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologyNeural StemMedicine +10

Creutzfeldt‐Jakob Disease: Carnoy's Fixative Improves the Immunohistochemistry of the Proteinase K‐ Resistant Prion Protein

Giorgio Giaccone, Barbara Canciani, Gianfranco Puoti, +6

Brain Pathology

Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease

Donato Goffredo, Dorotea Rigamonti, Chiara Zuccato, +3

Pharmacological Research

MedicinePotential Pharmacological TargetMolecular BiologyCell DeathDegenerative Disease +7

Differentiating embryonic stem–derived neural stem cells show a maturation-dependent pattern of voltage-gated sodium current expression and graded action potentials

Gerardo Biella, Francesca Di Febo, Donato Goffredo, +5

Neuroscience

Synaptic TransmissionCell PolarizationStem Cell BiologyCellular NeurobiologySynaptic Signaling +18