Oliver Poeschke

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

Trevor Dale, Paul A. Clarke, Christina Esdar et al. · Nature Chemical Biology · 2015 · 146 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +11

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

Aurélie Mallinger, Kai Schiemann, Christian Rink et al. · Journal of Medicinal Chemistry · 2016 · 112 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Aurélie Mallinger, Simon Crumpler, Mark Pichowicz et al. · Journal of Medicinal Chemistry · 2015 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +14

A Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease

Luuk de Haan, Johnny Suijker, Ruthger van Roey et al. · International Journal of Molecular Sciences · 2021 · 80 citations · Full text

Life Sciences, Cell Biology, Immunology +17

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19

Aurélie Mallinger, Kai Schiemann, Christian Rink et al. · ACS Medicinal Chemistry Letters · 2016 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16