Els Fransen

TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments

Johan Vingerhoets, Hilde Azijn, Els Fransen et al. · Journal of Virology · 2005 · 246 citations · Full text

Medicine, Molecular Genetics, Pharmacology +17

<i>In Vitro</i> Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Oliver Lenz, Thierry Verbinnen, Tse‐I Lin et al. · Antimicrobial Agents and Chemotherapy · 2010 · 211 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

Benoit Devogelaere, Jan Martin Berke, Leen Vijgen et al. · Antimicrobial Agents and Chemotherapy · 2012 · 46 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Sandrine Vendeville, Tse‐I Lin, Lili Hu et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 39 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +16

Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Maxwell D. Cummings, Tse‐I Lin, Lili Hu et al. · Journal of Medicinal Chemistry · 2013 · 37 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17