Tsuneo Yasuma

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami et al. · ACS Medicinal Chemistry Letters · 2010 · 247 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

TAK-875, an Orally Available G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist, Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats

Yoshiyuki Tsujihata, Ryo Ito, Masami Suzuki et al. · Journal of Pharmacology and Experimental Therapeutics · 2011 · 145 citations

Medicine, Endocrinology, Pharmacology +17

Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists

Shinobu Sasaki, Shuji Kitamura, Nobuyuki Negoro et al. · Journal of Medicinal Chemistry · 2011 · 87 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis of Peptide Aldehyde Derivatives as Selective Inhibitors of Human Cathepsin L and Their Inhibitory Effect on Bone Resorption

Tsuneo Yasuma, Satoru Oi, Nobuo Choh et al. · Journal of Medicinal Chemistry · 1998 · 75 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent

Nobuyuki Negoro, Shinobu Sasaki, Satoshi Mikami et al. · Journal of Medicinal Chemistry · 2012 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15