AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial

Jun Lv, Hui Wang, Xiaoting Cheng, +24

The Lancet

Gene TherapiesAav1-hotof Gene TherapySingle-arm TrialGeneticsAudiology +4

Defective Mitochondrial Dynamics Is an Early Event in Skeletal Muscle of an Amyotrophic Lateral Sclerosis Mouse Model

Luo Guo, Jianxun Yi, Changling Ma, +4

PLoS ONE

Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results

Hui Wang, Yuxin Chen, Jun Lv, +27

Nature Medicine

Age-related transcriptome changes in Sox2+ supporting cells in the mouse cochlea

Cheng Cheng, Yunfeng Wang, Luo Guo, +11

Stem Cell Research & Therapy

Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by <i>In Vivo</i> Genetic Reprogramming in the Neonatal Mouse Cochlea

Wenli Ni, Lin Chen, Luo Guo, +5

Journal of Neuroscience

Genetic testing for sporadic hearing loss using targeted massively parallel sequencing identifies 10 novel mutations

Xiaodong Gu, Luo Guo, Haiying Ji, +4

Clinical Genetics

Parallel SequencingGeneticsGenetic EpidemiologyPathologyTargeted Genome Enrichment +18

SASH1 regulates melanocyte transepithelial migration through a novel Gαs–SASH1–IQGAP1–E-Cadherin dependent pathway

Ding’an Zhou, Zhiyun Wei, Shanshan Deng, +8

Cellular Signalling

Signal TransductionSignaling PathwayMolecular PathwayCell RegulationMelanocyte Transepithelial Migration +6

Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea

Yan Chen, Xiaoling Lu, Luo Guo, +10

Frontiers in Molecular Neuroscience

Progenitor CellsGeneticsCell ProliferationCell SpecializationEmbryology +16

Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea

Xi Gu, Renjie Chai, Luo Guo, +5

Frontiers in Cellular Neuroscience

Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression

Yajuan Xiao, Changling Ma, Jianxun Yi, +6

Physiological Reports

MitophagyDisease ProgressionCell DeathCellular PhysiologyCell Autophagy +15