Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2- <i>a</i> ]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis

Nicolas Desroy, Christopher Housseman, Xavier Bock, +27

Journal of Medicinal Chemistry

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

Mathieu Pizzonero, Sonia Dupont, Marielle Babel, +28

Journal of Medicinal Chemistry

InflammationFrom HitMedicinal ChemistryAnti-inflammatoryBiochemistry +13

Effects of Strontium on the Physicochemical Characteristics of Hydroxyapatite

Steven Verberckmoes, Geert J. Behets, Line Oste, +8

Calcified Tissue International

HydroxyapatitePhysicochemical CharacteristicsBioceramicGeochemistryOsteoporosis

Localization of lanthanum in bone of chronic renal failure rats after oral dosing with lanthanum carbonate

Geert J. Behets, Steven Verberckmoes, Line Oste, +6

Kidney International

UrologyRenal FunctionMedicineKidney FailureLanthanum Carbonate +4

A multiparameter approach to monitor disease activity in collagen-induced arthritis

Sylvie Seeuws, Peggy Jacques, Jens Van Praet, +11

Arthritis Research & Therapy

Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats

Line Oste, An Bervoets, Geert J. Behets, +8

Kidney International

UrologyHealth SciencesKidney ResearchMedicinePhysiology +6

Discovery of 9-Cyclopropylethynyl-2-((<i>S</i>)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-<i>a</i>]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial

Frédéric Labéguère, Sonia Dupont, Luke J. Alvey, +28

Journal of Medicinal Chemistry

IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases

Stéphanie Lavazais, Manja Jargosch, Sonia Dupont, +17

Science Translational Medicine

Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis

Oscar Mammoliti, Adeline Palisse, Caroline Joannesse, +17

Journal of Medicinal Chemistry

Development and reversibility of impaired mineralization associated with lanthanum carbonate treatment in chronic renal failure rats

An Bervoets, Line Oste, Geert J. Behets, +6

Bone

UrologyRenal FunctionLanthanum Carbonate TreatmentSodium HomeostasisMedicine +10