Somhairle MacCormick

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Philip M. Reaper, Matthew R. Griffiths, Joanna Long et al. · Nature Chemical Biology · 2011 · 639 citations

Life Sciences, Molecular Biology, Oncology +14

Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

Jean‐Damien Charrier, Steven J. Durrant, Julian M.C. Golec et al. · Journal of Medicinal Chemistry · 2011 · 259 citations · Full text

Life Sciences, Medicinal Chemistry, Oncology +15

Rational Design of 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor

Ronald M. A. Knegtel, Jean‐Damien Charrier, Steven J. Durrant et al. · Journal of Medicinal Chemistry · 2019 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

A preliminary evaluation of a metathesis approach to bryostatins

Matthew Ball, Ben Bradshaw, Raphaël Dumeunier et al. · Tetrahedron Letters · 2006 · 41 citations

Pharmacy, Medicinal Chemistry, Pharmacology +3

A stereoselective synthesis of the C(1)–C(16) fragment of the bryostatins

Matthew Ball, Anne Baron, Ben Bradshaw et al. · Tetrahedron Letters · 2004 · 24 citations

Natural Sciences, Chemistry, Medicinal Chemistry +7