Akihiro Tasaka

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Tomohiro Kaku, Takenori Hitaka, Akio Ojida et al. · Bioorganic & Medicinal Chemistry · 2011 · 126 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Total Synthesis of (−)-Bafilomycin A₁

Karl A. Scheidt, Thomas D. Bannister, Akihiro Tasaka et al. · Journal of the American Chemical Society · 2002 · 123 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys

Masuo Yamaoka, Takahito Hara, Takenori Hitaka et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 116 citations

Life Sciences, Endocrinology, Pharmacology +17

Total Synthesis of (−)-Bafilomycin A1: Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions

Karl A. Scheidt, Akihiro Tasaka, Thomas D. Bannister et al. · Angewandte Chemie International Edition · 1999 · 61 citations

Pharmacy, Medicinal Chemistry, Drug Discovery +13

C17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors

Nobuyuki Matsunaga, Tomohiro Kaku, Akio Ojida et al. · Bioorganic & Medicinal Chemistry · 2004 · 56 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14