Dizhong Chen

Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma

Anthony D. William, Angeline C.-H. Lee, Stéphanie Blanchard et al. · Journal of Medicinal Chemistry · 2011 · 194 citations · Full text

Janus Kinase 2, Pharmacotherapy, Tumor Biology +19

Discovery of (2<i>E</i>)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1<i>H</i>-benzimidazol-5-yl}-<i>N</i>-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

Haishan Wang, Niefang Yu, Dizhong Chen et al. · Journal of Medicinal Chemistry · 2011 · 91 citations · Full text

Discovery of the Macrocycle (9<i>E</i>)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a Potent Inhibitor of Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) for the Treatment of Rheumatoid Arthritis

Anthony D. William, Angeline C.-H. Lee, Anders Poulsen et al. · Journal of Medicinal Chemistry · 2012 · 52 citations · Full text

Potent Inhibitor, Immunology, Biological Therapy +17

Structure and Ligand-Based Design of mTOR and PI3-Kinase Inhibitors Leading to the Clinical Candidates VS-5584 (SB2343) and SB2602

Anders Poulsen, Harish Nagaraj, Angeline Lee et al. · Journal of Chemical Information and Modeling · 2014 · 29 citations

Phenol Headgroup, Pharmacotherapy, Cancer Biology +21

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity

Haishan Wang, Niefang Yu, Hongyan Song et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 29 citations · Full text

Medicinal Chemistry, Medicine, N-hydroxy-1,2-disubstituted-1h-benzimidazol-5-yl Acrylamides +9