Reactions of salicylaldehydes with alkyl cyanoacetates on the surface of solid catalysts: syntheses of 4H-chromene derivatives

Niefang Yu, James M. Aramini, Markus W. Germann, +1

Tetrahedron Letters

Materials ScienceEngineeringAlkene MetathesisOrganic ChemistryOrganometallic Catalysis +8

Discovery of (2<i>E</i>)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1<i>H</i>-benzimidazol-5-yl}-<i>N</i>-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

Haishan Wang, Niefang Yu, Dizhong Chen, +24

Journal of Medicinal Chemistry

Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate

Jiahui Wu, Dengyou Zhang, Lei Chen, +10

Journal of Medicinal Chemistry

Sirt1 ActivatorsCrystal StructureProtein FunctionSignal TransductionProtein Assembly +13

Macrocyclic compounds as anti-cancer agents: Design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2

Chengqing Ning, Cheng Lu, Liang Hu, +6

European Journal of Medicinal Chemistry

Anti-cancer AgentsCombinatorial ChemistryMedicinal ChemistryMedicineMacrocyclic Compounds +7

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity

Haishan Wang, Niefang Yu, Hongyan Song, +20

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineN-hydroxy-1,2-disubstituted-1h-benzimidazol-5-yl AcrylamidesVivo Antitumor ActivityPharmacotherapy +7

Lewis acid-induced reaction of homophthalic anhydride with imines: a convenient synthesis of trans-isoquinolonic acids

Niefang Yu, Line Bourel‐Bonnet, Benoît Déprez, +1

Tetrahedron Letters

Homophthalic AnhydrideBiochemistryNatural SciencesOrganic ChemistryChemistry +5

Design, synthesis and biological evaluation of di-substituted cinnamic hydroxamic acids bearing urea/thiourea unit as potent histone deacetylase inhibitors

Chengqing Ning, Yan-Jing Bi, Yujun He, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesUrea/thiourea Unit +6

PLK1 as a potential drug target in cancer therapy

Kee Chuan Goh, Haishan Wang, Niefang Yu, +16

Drug Development Research

Tumor BiologyOncologyRing SystemMedicineCancer Cell Biology +10

Cycloaddition of homophthalic anhydrides with aldehydes and ketones: a route to 3,4-dihydroisocoumarin-4-carboxylic acid derivatives

Niefang Yu, Rebecca Deprez‐Poulain, André Tartar, +1

Tetrahedron

3,4-Dihydroisocoumarin-4-carboxylic Acid DerivativesDerivative (Chemistry)EngineeringHeterocyclicBiochemistry +6

Design, synthesis and biological evaluation of indeno[1,2-d]thiazole derivatives as potent histone deacetylase inhibitors

Ming Zhou, Chengqing Ning, Ruihuan Liu, +2

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesOrganic Chemistry +7