Michelle E. Pizzo

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Mihalis S. Kariolis, Robert C. Wells, Jennifer A. Getz et al. · Science Translational Medicine · 2020 · 355 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

Michelle E. Pizzo, Daniel J. Wolak, Niyanta Kumar et al. · The Journal of Physiology · 2017 · 285 citations · Full text

Life Sciences, Immunology, Neuroscience +17

Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration

Jeffrey J. Lochhead, Daniel J. Wolak, Michelle E. Pizzo et al. · Journal of Cerebral Blood Flow & Metabolism · 2014 · 253 citations · Full text

Pharmacy, Neuroscience, Pharmacology +15

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

Todd Logan, Matthew Simon, Gerald Maxwell Cherf et al. · Cell · 2021 · 229 citations · Full text

Life Sciences, Genetics, Neuroscience +12

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Bettina van Lengerich, Lihong Zhan, Dan Xia et al. · Nature Neuroscience · 2023 · 222 citations · Full text

Medicine, Neurobiology, Neuroscience +17