A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

Anuradha Illendula, John Anto Pulikkan, Hongliang Zong, +11

Science

Hematological MalignancyCancer ResearchAdult LeukemiaCell RegulationMedicine +9

Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways

Duane C. Hassane, Siddhartha Sen, Mohammad Minhajuddin, +7

Blood

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

Hongliang Zong, Alexander Gozman, Eloisi Caldas-Lopes, +16

Cell Reports

The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks

Gulshan Sunavala‐Dossabhoy, Sri Kripa Balakrishnan, Siddhartha Sen, +2

BMC Molecular Biology

Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity

Siddhartha Sen, Duane C. Hassane, Cheryl A. Corbett, +3

Experimental Hematology

BiochemistryMedicineNatural SciencesImmunologyMechanism Of Action +7

CTLA-4 Blockade Plus Adoptive T-Cell Transfer Promotes Optimal Melanoma Immunity in Mice

David A. Mahvi, Justin V. Meyers, Andrew J. Tatar, +5

Journal of Immunotherapy

ImmunologyImmunoeditingImmunotherapeuticsImmune Cell TherapyImmunotherapy +19

TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1.

Siddhartha Sen, Arrigo De Benedetti

BMC Molecular Biology

TLK1B is elevated with eIF4E overexpression in breast cancer

Kathryn S Norton, Derek R. McClusky, Siddhartha Sen, +4

Journal of Surgical Research

Breast OncologyMedicinePathologyBreast CancerCancer Genetics +3

Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy

Tony Taldone, Erica M. Gomes-DaGama, Hongliang Zong, +6

Bioorganic & Medicinal Chemistry Letters

Purine-scaffold Fluorescent ProbesFluorescence MicroscopyImmunocytochemical TechniqueHeat ShockNatural Sciences +8

Monoclonal antibodies against IREM-1: potential for targeted therapy of AML

Wouter Korver, Xiaoxian Zhao, Shweta Singh, +14

Leukemia

ImmunologyHematologyMonoclonal AntibodiesBiological TherapyAntibody Engineering +5