Alexander Gozman

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

Eloisi Caldas-Lopes, Leandro Cerchietti, James H. Ahn et al. · Proceedings of the National Academy of Sciences · 2009 · 315 citations · Full text

Medicine, Oncology, Pharmacology +17

Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

Anna Rodina, Pallav D. Patel, Yanlong Kang et al. · Chemistry & Biology · 2013 · 102 citations

Life Sciences, Biochemistry, Molecular Biology +14

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

Hongliang Zong, Alexander Gozman, Eloisi Caldas-Lopes et al. · Cell Reports · 2015 · 64 citations · Full text

Medicine, Cancer Biology, Oncology +17

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

Yanlong Kang, Tony Taldone, Hardik J. Patel et al. · Journal of Medicinal Chemistry · 2014 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90

Iwona Wrona, Alexander Gozman, Tony Taldone et al. · The Journal of Organic Chemistry · 2010 · 59 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17