Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway

Jinghe Li, Ryota Inoue, Yu Togashi, +13

Diabetes

ApoptosisImmunologyCell DeathEr StressInsulin Signaling +14

Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes

Yoshimi Nakagawa, Aoi Satoh, Sachiko Yabe, +28

Endocrinology

Metabolic RemodelingInsulin SignalingImproves ObesityObesityMetabolic Syndrome +20

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα

Yoshimi Nakagawa, Aoi Satoh, Hitomi Tezuka, +11

Scientific Reports

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

Takuya Kikuchi, Kana Orihara, Fusaka Oikawa, +17

Molecular Metabolism

Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

Yoshimi Nakagawa, Fusaka Oikawa, Seiya Mizuno, +18

Scientific Reports

Selective peroxisome proliferator‐activated receptor‐α modulator K‐877 efficiently activates the peroxisome proliferator‐activated receptor‐α pathway and improves lipid metabolism in mice

Kenta Takei, Song‐iee Han, Yuki Murayama, +13

Journal of Diabetes Investigation

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice

Kenta Takei, Yoshimi Nakagawa, Yunong Wang, +5

Journal of Pharmacological Sciences

TFE3 Controls Lipid Metabolism in Adipose Tissue of Male Mice by Suppressing Lipolysis and Thermogenesis

Yuri Fujimoto, Yoshimi Nakagawa, Aoi Satoh, +16

Endocrinology

Lipase ActivityInsulin SignalingObesityMetabolic SyndromeTranscriptional Regulation +16

Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells

Yuri Fujimoto, Yoshimi Nakagawa, Akiko Shingyouchi, +13

Biochemical and Biophysical Research Communications

Developmental BiologyCell SignalingAdipocyte DifferentiationMetabolic RegulationGene Expression +5

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

Aoi Satoh, Song‐iee Han, Masaya Araki, +13

iScience