Paul Hessler

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Loren Lasko, Clarissa G. Jakob, Rohinton Edalji et al. · Nature · 2017 · 858 citations · Full text

Medicine, Cancer Biology, Oncology +8

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Emily J. Faivre, Keith F. McDaniel, Daniel H. Albert et al. · Nature · 2020 · 404 citations

Life Sciences, Molecular Biology, Oncology +10

Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line

Wiweka Kaszubska, Hugh D. Falls, Verlyn G. Schaefer et al. · Molecular and Cellular Endocrinology · 2002 · 187 citations

Life Sciences, Biochemistry, Endocrinology +14

Potential mechanisms of resistance to venetoclax and strategies to circumvent it

Stephen K. Tahir, Morey L. Smith, Paul Hessler et al. · BMC Cancer · 2017 · 187 citations · Full text

Medicine, Oncology, Pharmacology +17

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor

Yu Xiao, Paul Nimmer, George S. Sheppard et al. · Molecular Cancer Therapeutics · 2015 · 122 citations · Full text

Medicine, Oncology, Pharmacology +17