The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.

David W. Rusnak, Karen Affleck, Stuart Cockerill, +22

PubMed

Potential TherapyTumor BiologyOncologyDual Erbb-2/egfrReceptor Tyrosine Kinase +16

Urotensin II Acts Centrally to Increase Epinephrine and ACTH Release and Cause Potent Inotropic and Chronotropic Actions

Anna M.D. Watson, Gavin Lambert, Kathryn J. Smith, +1

Hypertension

Heart FailureSmall PeptideCardiovascular FunctionActh ReleaseAdrenal Gland +20

Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and c-erbB-2

Stuart Cockerill, Colin Stubberfield, Jeremy N. Stables, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryIndazolylamino QuinazolinesMedicinePharmacological AgentPharmacotherapy +8

Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity

Richard Angell, Paul Bamborough, Jacky B. Buckton, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryVivo ActivityChemoprevention StrategyMedicineKinase Inhibitors 3 +9

Discovery and Biological Evaluation of Potent Dual ErbB-2/EGFR Tyrosine Kinase Inhibitors: 6-Thiazolylquinazolines

Micheal D. Gaul, Yu Guo, Karen Affleck, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineRational Drug DesignPharmacotherapyBiological Evaluation +5

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes

Richard Angell, Tony D. Angell, Paul Bamborough, +13

Bioorganic & Medicinal Chemistry Letters

Molecular DockingMedicinal ChemistryDfg-out Binding ModesDrug TargetBiochemistry +10

N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics

Paul Bamborough, Richard Angell, Inder Bhamra, +14

Bioorganic & Medicinal Chemistry Letters

Phenol IsosteresPharmacological StudyMedicinePharmacological AgentPharmacotherapy +5

Development and Validation of a Situational Judgement Test to Assess Professionalism

Kathryn J. Smith, Charlotte Flaxman, Michelle Z. Farland, +4

American Journal of Pharmaceutical Education

Chemical synthesis and biological activity of rat INSL3

Kathryn J. Smith, John D. Wade, Antonia A. Claasz, +6

Journal of Peptide Science

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

John Liddle, Paul Bamborough, Michael D. Barker, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineSelective Ikk2 InhibitorsAnti-cancer AgentHeterocycle Chemistry +3