Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

Keertik Fulzele, Ryan C. Riddle, Douglas J. DiGirolamo, +8

Cell

SclerostinDevelopmental BiologyBody CompositionBone Morphogenic ProteinPhysiology +9

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

Daniel A. Lee, Joseph L. Bedont, Thomas Pak, +11

Nature Neuroscience

Energy HomeostasisDevelopmental BiologyNeurophysiologyNeuroanatomyMedicine +11

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Mali Jiang, Jiawei Wang, Jinrong Fu, +27

Nature Medicine

Mammalian ModelsGeneticsCell DeathDegenerative PathologyNeuroprotection +6

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

Eun Kyoung Kim, Ian Miller, Susan Aja, +6

Journal of Biological Chemistry

NutritionReduces Food IntakeFood IntakeCaloric RestrictionObesity +14

Deletion of <i>TDP-43</i> down-regulates <i>Tbc1d1</i> , a gene linked to obesity, and alters body fat metabolism

Po‐Min Chiang, Jonathan P. Ling, Yun Ha Jeong, +3

Proceedings of the National Academy of Sciences

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

Soona Shin, Junko Wakabayashi, Melinda S. Yates, +7

European Journal of Pharmacology

ObesityMetabolic SyndromeHigh-fat Diet-induced ObesitySynthetic Triterpenoid Cddo-imidazolideBiochemistry +9

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Su Gao, Kimberly P. Kinzig, Susan Aja, +13

Proceedings of the National Academy of Sciences

NutritionFood IntakeHypothalamic CircuitsGastrointestinal Peptide HormoneMetabolic Syndrome +14

Knockdown of NPY Expression in the Dorsomedial Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced Obesity

Pei-Ting Chao, Liang Yang, Susan Aja, +2

Cell Metabolism

ObesityMetabolic SyndromeEnergy HomeostasisInsulin SignalingDevelopmental Biology +11

The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

Zhongyan Zhang, Nobunao Wakabayashi, Junko Wakabayashi, +12

Molecular Biology of the Cell

Cell DeathCellular PhysiologyInsulin SignalingOxidative StressBeta Cells +22

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

Soohyun P. Kim, Julie L. Frey, Zhu Li, +11

Proceedings of the National Academy of Sciences