Graeme J. Moffat

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

Simon A. Chanas, Qingwu Jiang, Michael McMahon et al. · Biochemical Journal · 2002 · 443 citations · Full text

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

John D. Hayes, Simon A. Chanas, Colin J. Henderson et al. · Biochemical Society Transactions · 2000 · 318 citations

Reductive Stress, Chemoprevention Strategy, Biochemistry +15

Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver.

Vincent P. Kelly, Elizabeth M. Ellis, Margaret M. Manson et al. · PubMed · 2000 · 146 citations

Pathology, Redox Biology, Toxicological Mechanism +19

The Practical Application of Three Validated <i>In Vitro</i> Embryotoxicity Tests

Horst Spielmann, A. Seiler, Susanne Bremer et al. · Alternatives to Laboratory Animals · 2006 · 130 citations

Hazard Potentials, Fertility, Genetics +20

Structural features of the human C3 gene: Intron/exon organization, transcriptional start site, and promoter region sequence

D P Vik, Patrick Amiguet, Graeme J. Moffat et al. · Biochemistry · 1991 · 97 citations