Alexander L. Ruchelman

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Mary E. Matyskiela, Gang Lu, Takumi Ito et al. · Nature · 2016 · 628 citations

Protein Function, Signal Transduction, Cell Regulation +10

5-(2-Aminoethyl)dibenzo[<i>c</i>,<i>h</i>][1,6]naphthyridin-6-ones:  Variation of <i>N</i>-Alkyl Substituents Modulates Sensitivity to Efflux Transporters Associated with Multidrug Resistance

Alexander L. Ruchelman, Peter J. Houghton, Nai Zhou et al. · Journal of Medicinal Chemistry · 2005 · 110 citations

Pharmaceutical Science, Multidrug Resistance, Pharmacotherapy +20

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-Targeting anticancer agents with potent cytotoxic activity

Alexander L. Ruchelman, Sudhir Singh, Abhijit Ray et al. · Bioorganic & Medicinal Chemistry · 2003 · 109 citations

Medicinal Chemistry, Drug Targeting, Medicine +7

Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.

Tsai‐Kun Li, Peter J. Houghton, Shyamal D. Desai et al. · PubMed · 2003 · 95 citations

Unlike Cpt, Drug Targeting, Oncology +12

11H-Isoquino[4,3-c]cinnolin-12-ones

Alexander L. Ruchelman · Bioorganic & Medicinal Chemistry · 2004 · 80 citations