Yafan Lu

Aminoethylenes:  A Tetrahedral Intermediate Isostere Yielding Potent Inhibitors of the Aspartyl Protease BACE-1

Wenjin Yang, Wanli Lu, Yafan Lu et al. · Journal of Medicinal Chemistry · 2006 · 52 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Fragment-Based Discovery of Nonpeptidic BACE-1 Inhibitors Using Tethering

Wenjin Yang, Raymond V. Fucini, Bruce J. Fahr et al. · Biochemistry · 2009 · 49 citations

Life Sciences, Biochemistry, Medicinal Chemistry +17

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late <i>I</i>_Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties

Jeff Zablocki, Elfatih Elzein, Xiaofen Li et al. · Journal of Medicinal Chemistry · 2016 · 34 citations · Full text

Medicine, Cardiology, Pharmacology +17

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

Raymond V. Fucini, Emily J. Hanan, M.J. Romanowski et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties

Ingrid Choong, Iana M. Serafimova, Junfa Fan et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 11 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +13