Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks

Andrey Morgun, Amiran Dzutsev, Xiaoxi Dong, +7

Gut

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

Renee L. Greer, Xiaoxi Dong, Ana Carolina Franco de Moraes, +16

Nature Communications

Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results

Christine D. Palmer, Amy Rappaport, Matthew J. Davis, +41

Nature Medicine

VaccinationVaccine DevelopmentMedicineImmunologyVirology +5

Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes

Richard R. Rodrigues, Manoj Gurung, Zhipeng Li, +17

Nature Communications

Antibiotic-Induced Alterations in Gut Microbiota Are Associated with Changes in Glucose Metabolism in Healthy Mice

Richard R. Rodrigues, Renee L. Greer, Xiaoxi Dong, +5

Frontiers in Microbiology

CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont

Natalia Shulzhenko, Xiaoxi Dong, Dariia Vyshenska, +11

Clinical Immunology

InflammationInterferon-driven InflammationAutoimmune DiseaseMucosal ImmunologyPathogenesis +9

Arsenic exposure and intestinal microbiota in children from Sirajdikhan, Bangladesh

Xiaoxi Dong, Natalia Shulzhenko, Julien Lemaître, +10

PLoS ONE

Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by <i>Mmp12</i>+ macrophages

Zhipeng Li, Manoj Gurung, Richard R. Rodrigues, +16

The Journal of Experimental Medicine

DysbiosisImmunologyMetabolic RemodelingInsulin SignalingOxidative Stress +21

Dicer Regulates Differentiation and Viability during Mouse Pancreatic Cancer Initiation

John P. Morris, Renee L. Greer, Holger A. Russ, +8

PLoS ONE

PathologyCancer BiologyTumor BiologyDicer Regulates DifferentiationPancreatic Cancer +14

Numb Regulates Acinar Cell Dedifferentiation and Survival During Pancreatic Damage and Acinar-to-Ductal Metaplasia

Renee L. Greer, Binnaz K. Staley, Angela Liou, +1

Gastroenterology

Pancreatic CancerPathologyAcinar-to-ductal MetaplasiaPancreatic SurgeryPancreatic Damage +3