Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

Fabio Pessina, Fabio Giavazzi, Yandong Yin, +11

Nature Cell Biology

ChromatinTranscriptional RegulationDna Double-strand BreaksNatural SciencesGenetics +9

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

Fabio Iannelli, Alessandro Galbiati, Ilaria Capozzo, +11

Nature Communications

A novel single-cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues

Alessandro Galbiati, Christian Beauséjour, Fabrizio d’Adda di Fagagna

Aging Cell

Dna DamageImmunologyNovel Single-cell MethodCell DeathMolecular Biology +23

Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends

Michela Clerici, Camilla Trovesi, Alessandro Galbiati, +2

The EMBO Journal

ChromatinGenome InstabilityNatural SciencesGeneticsSingle-stranded Dna +9

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends

Sheetal Sharma, Roopesh Anand, Xuzhu Zhang, +9

Cell Reports

Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta

Martin L. Stockley, Amanda Ferdinand, Giovanni Benedetti, +30

Journal of Medicinal Chemistry

Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

Gonzalo Rodríguez‐Berriguete, Marco Ranzani, Remko Prevo, +21

Clinical Cancer Research

Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition

Kunzah Jamal, Alessandro Galbiati, Joshua Armenia, +8

Cancer Research Communications

DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining

Matteo Cabrini, Marco Roncador, Alessandro Galbiati, +6

Journal of Cell Science

DNA Damage In Situ Ligation Followed by Proximity Ligation Assay (DI-PLA)

Alessandro Galbiati, Fabrizio d’Adda di Fagagna

Methods in molecular biology

ChromatinGenome InstabilityDna SequencingDna DamageMolecular Biological Method +10