Jade Laguer

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS ^G12D Inhibitor

Xiaolun Wang, Shelley Allen, James F. Blake et al. · Journal of Medicinal Chemistry · 2021 · 708 citations · Full text

Medicine, Medicinal Chemistry, Oncology +14

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

Jill Hallin, Vickie Bowcut, Andrew Calinisan et al. · Nature Medicine · 2022 · 507 citations

Medicine, Medicinal Chemistry, Oncology +9

Autophagy-mediated longevity is modulated by lipoprotein biogenesis

Nicole Seah, C. Daniel De Magalhaes Filho, Anna P. Petrashen et al. · Autophagy · 2015 · 130 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

John M. Ketcham, Jacob R. Haling, Shilpi Khare et al. · Journal of Medicinal Chemistry · 2022 · 94 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading

Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos et al. · Molecular Cancer Therapeutics · 2024 · 32 citations · Full text

Medicine, Oncology, Pharmacology +14