Bradford A. Youngblood

AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice

Bradford A. Youngblood, Emily C. Brock, John Leung et al. · International Archives of Allergy and Immunology · 2019 · 110 citations · Full text

Life Sciences, Immunology, Pharmacology +16

Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody

Simon Gebremeskel, Julia Schanin, Krysta M. Coyle et al. · Frontiers in Immunology · 2021 · 108 citations · Full text

Life Sciences, Immunology, Pathology +17

Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis

Bradford A. Youngblood, Emily C. Brock, John Leung et al. · JCI Insight · 2019 · 105 citations · Full text

Life Sciences, Immunology, Pathology +17

A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation

Julia Schanin, Simon Gebremeskel, Wouter Korver et al. · Mucosal Immunology · 2020 · 75 citations · Full text

Life Sciences, Immunology, Pathobiology +17

Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

Fanny Legrand, Yun Cao, Joshua B. Wechsler et al. · Journal of Allergy and Clinical Immunology · 2018 · 59 citations · Full text

Life Sciences, Immunology, Pathology +16