Allakos (United States)

Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis

Evan S. Dellon, Kathryn A. Peterson, Joseph A. Murray et al. · New England Journal of Medicine · 2020 · 252 citations · Full text

Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody

Simon Gebremeskel, Julia Schanin, Krysta M. Coyle et al. · Frontiers in Immunology · 2021 · 106 citations · Full text

AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice

Bradford A. Youngblood, Emily C. Brock, John Leung et al. · International Archives of Allergy and Immunology · 2019 · 104 citations · Full text

Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis

Bradford A. Youngblood, Emily C. Brock, John Leung et al. · JCI Insight · 2019 · 103 citations · Full text

Immunodeficiencies, Immunology, Gastroenterology +19

Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis

Paul Bryce, Rustom Falahati, Laurie L. Kenney et al. · Journal of Allergy and Clinical Immunology · 2016 · 100 citations

Inflammation, Allergy, Lung Inflammation +12