Krzysztof Pawełczak

Syntheses and thymidylate synthase inhibitory activity of the poly-.gamma.-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates

Graham M. F. Bisset, Krzysztof Pawełczak, Ann L. Jackman et al. · Journal of Medicinal Chemistry · 1992 · 34 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Trichinella spiralisThymidylate Synthase: Developmental Pattern, Isolation, Molecular Properties, and Inhibition by Substrate and Cofactor Analogues

Magdalena Dąbrowska, Zbigniew Zieliński, M. Wranicz et al. · Biochemical and Biophysical Research Communications · 1996 · 28 citations

Pharmacy, Biochemistry, Microbiology +10

Quinazoline antifolates inhibiting thymidylate synthase: synthesis of four oligo(L-.gamma.-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid and their enzyme inhibition

Krzysztof Pawełczak, Terence R. Jones, Michał Kempny et al. · Journal of Medicinal Chemistry · 1989 · 26 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +8

The Synthesis and Thymidylate Synthase Inhibitory Activity of L-.gamma.-L-Linked Dipeptide and L-.gamma.-Amide Analogs of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

Graham M. F. Bisset, Vassilios Bavetsias, Krzysztof Pawełczak et al. · Journal of Medicinal Chemistry · 1994 · 16 citations · Full text

Natural Sciences, Chemistry, Pharmacology +6

Quinazoline Antifolate Thymidylate Synthase Inhibitors: Replacement of Glutamic Acid by Aminophosphonic Acids

Maciej Makowski, Krzysztof Pawełczak, Paweł Kafarski et al. · Phosphorus, sulfur, and silicon and the related elements · 2003 · 12 citations

Pharmacy, Medicinal Chemistry, Pharmacology +8