Pascal E. Sanchez

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

Alicia Nugent, Karin Lin, Bettina van Lengerich et al. · Neuron · 2020 · 748 citations · Full text

Life Sciences, Cell Biology, Immunology +14

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model

Pascal E. Sanchez, Laure Verret, Keith Vossel et al. · Proceedings of the National Academy of Sciences · 2012 · 647 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

Elsa Suberbielle, Pascal E. Sanchez, Alexxai V. Kravitz et al. · Nature Neuroscience · 2013 · 489 citations · Full text

Life Sciences, Neurobiology, Neuroscience +14

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Mihalis S. Kariolis, Robert C. Wells, Jennifer A. Getz et al. · Science Translational Medicine · 2020 · 355 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

Todd Logan, Matthew Simon, Gerald Maxwell Cherf et al. · Cell · 2021 · 229 citations · Full text

Life Sciences, Genetics, Neuroscience +12