Pascal E. Sanchez

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

Alicia Nugent, Karin Lin, Bettina van Lengerich et al. · Neuron · 2020 · 697 citations · Full text

Inflammation, Immunology, Chronic Inflammation +7

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model

Pascal E. Sanchez, Lei Zhu, Laure Verret et al. · Proceedings of the National Academy of Sciences · 2012 · 636 citations · Full text

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

Elsa Suberbielle, Pascal E. Sanchez, Alexxai V. Kravitz et al. · Nature Neuroscience · 2013 · 481 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, Dna Damage +12

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Mihalis S. Kariolis, Robert C. Wells, Jennifer A. Getz et al. · Science Translational Medicine · 2020 · 331 citations

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Bettina van Lengerich, Lihong Zhan, Dan Xia et al. · Nature Neuroscience · 2023 · 213 citations · Full text