Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang, Shengqing Gu, Deng Pan, +12

Nature Medicine

Cancer ImmunosurveillanceT Cell DysfunctionT-regulatory CellImmunologyTumor Immunity +8

TRUST4: immune repertoire reconstruction from bulk and single-cell RNA-seq data

Li Song, David Cohen, Zhangyi Ouyang, +3

Nature Methods

BioinformaticsImmunogeneticsSystems BiologyFunctional GenomicsSingle Cell Sequencing +11

Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma

Christopher D. Carey, Daniel Gusenleitner, Mikel Lipschitz, +11

Blood

Reconstruction of enhancer–target networks in 935 samples of human primary cells, tissues and cell lines

Qin Cao, Christine Anyansi, Xihao Hu, +9

Nature Genetics

Human CellSystems BiologyMedicineCell LinesHuman Primary Cells +6

Landscape of B cell immunity and related immune evasion in human cancers

Xihao Hu, Jian Zhang, Jin Wang, +17

Nature Genetics

Cancer ImmunosurveillanceB Cell ImmunityImmunologyTumor ImmunityImmunoediting +5

Mass cytometry of Hodgkin lymphoma reveals a CD4+ regulatory T-cell–rich and exhausted T-effector microenvironment

Fathima Zumla Cader, Ron C.J. Schackmann, Xihao Hu, +14

Blood

A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma

Fathima Zumla Cader, Xihao Hu, Walter L. Goh, +15

Nature Medicine

Lymphoid NeoplasiaCancer ImmunosurveillanceAutoimmune DiseasePd-1 BlockadeImmunology +10

Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells

Yuanchao Xue, Hao Qian, Jing Hu, +6

Nature Neuroscience

Developmental BiologyMolecular NeuroscienceBrain CircuitryNeurodynamicsCellular Neuroscience +10

Improved prediction of RNA secondary structure by integrating the free energy model with restraints derived from experimental probing data

Yang Wu, Binbin Shi, Xinqiang Ding, +6

Nucleic Acids Research

Structural BioinformaticsMolecular BiologySequence AlignmentPerfect RestraintsLong Non-coding Rna +17

Immune receptor repertoires in pediatric and adult acute myeloid leukemia

Jian Zhang, Xihao Hu, Jin Wang, +14

Genome Medicine