Karina Wong

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Anh P. Truong, G. Toth, Gary D. Probst et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 48 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

Gary D. Probst, Simeon Bowers, Jennifer M. Sealy et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 44 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14

Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Anh P. Truong, Danielle L. Aubele, Gary D. Probst et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Gary D. Probst, Danielle L. Aubele, Simeon Bowers et al. · Journal of Medicinal Chemistry · 2013 · 32 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

Simeon Bowers, Anh P. Truong, R. Jeffrey Neitz et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 32 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12