Pearl Tanaka

In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain

M. Bergeron, Ruth Motter, Pearl Tanaka et al. · Neuroscience · 2013 · 50 citations

Life Sciences, Molecular Biology, Neuroscience +10

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

Danielle L. Aubele, Roy K. Hom, Marc Adler et al. · ChemMedChem · 2013 · 49 citations

Life Sciences, Medicinal Chemistry, Pharmacology +12

Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

Albert W. Garofalo, Marc Adler, Danielle L. Aubele et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 34 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Gary D. Probst, Danielle L. Aubele, Simeon Bowers et al. · Journal of Medicinal Chemistry · 2013 · 32 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Simeon Bowers, Anh P. Truong, Michael Ye et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 30 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11