Lance Goulet

Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

Deepak Dalvie, R. Scott Obach, Ping Kang et al. · Chemical Research in Toxicology · 2009 · 187 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

An Autotaxin/Lysophosphatidic Acid/Interleukin‐6 Amplification Loop Drives Scleroderma Fibrosis

Flavia V. Castelino, Gretchen Bain, Veronica A. Pace et al. · Arthritis & Rheumatology · 2016 · 96 citations · Full text

Veterinary Medicine, Immunology, Pathology +17

Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design

Hengmiao Cheng, Chunze Li, Simon Bailey et al. · ACS Medicinal Chemistry Letters · 2012 · 81 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Identification of Novel HSP90α/β Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington’s Disease

Justin T. Ernst, Timothy D. Neubert, Michael C. Liu et al. · Journal of Medicinal Chemistry · 2014 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

Martin W. Rowbottom, Gretchen Bain, Imelda Calderon et al. · Journal of Medicinal Chemistry · 2017 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15