Assessment of Acetylcholinesterase Activity Using Indoxylacetate and Comparison with the Standard Ellman’s Method

Miroslav Pohanka, Martina Hrabinová, Kamil Kuča, +1

International Journal of Molecular Sciences

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Eugenie Nepovimová, Jan Korábečný, Rafael Doležal, +13

Journal of Medicinal Chemistry

Tacrine-trolox HybridsTacrine–trolox HybridsMedicinal ChemistryCentrally ActiveVivo Toxicity +13

Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors

Slávka Hamuľaková, Ladislav Janovec, Martina Hrabinová, +5

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +17

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

J Jerábek, Elisa Uliassi, Laura Guidotti, +11

European Journal of Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseMedicineTacrine-resveratrol Fused HybridsNeurochemical Biomarkers +3

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

Katarina Chalupova, Jan Korábečný, Manuela Bartolini, +32

European Journal of Medicinal Chemistry

NeuropeptidesDrug TargetBiochemistryFunctional SelectivityMedicine +9

Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules

Slávka Hamuľaková, Patrik Poprac, Klaudia Jomová, +12

Journal of Inorganic Biochemistry

Acetylcholinesterase SystemAlzheimer's DiseaseBiochemistryMedicineBioactive Metal +6

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease

Vendula Hepnarová, Jan Korábečný, Lenka Matoušková, +16

European Journal of Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseMedicineHybrid MoleculesPharmacological Agent +11

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

Kamil Kuča, Kamil Musílek, Daniel Jun, +10

BMC Pharmacology and Toxicology

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation

Katarína Špilovská, Jan Korábečný, Vendula Šepsová, +11

Molecules

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

Jan Korábečný, Martin Andrš, Eugenie Nepovimová, +11

Molecules

Neurochemical Biomarkers7-Methoxytacrine-p-anisidine HybridsPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +17