Rafael Doležal

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Eugenie Nepovimová, Jan Korábečný, Rafael Doležal et al. · Journal of Medicinal Chemistry · 2015 · 129 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

Katarina Chalupova, Jan Korábečný, Manuela Bartolini et al. · European Journal of Medicinal Chemistry · 2019 · 110 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies

Jan Korábečný, Rafael Doležal, Pavla Cabelova et al. · European Journal of Medicinal Chemistry · 2014 · 81 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease

Vendula Hepnarová, Jan Korábečný, Lenka Matoušková et al. · European Journal of Medicinal Chemistry · 2018 · 70 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies

Rafael Doležal, Ondřej Soukup, David Maliňák et al. · European Journal of Medicinal Chemistry · 2016 · 63 citations

Pharmacy, Chemistry, Medicinal Chemistry +17