A perspective on multi‐target drug discovery and design for complex diseases

Rona R. Ramsay, Marija R. Popović-Nikolić, Katarina Nikolić, +2

Clinical and Translational Medicine

Drug TargetHit IdentificationChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +18

Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

Eugenie Nepovimová, Elisa Uliassi, Jan Korábečný, +13

Journal of Medicinal Chemistry

Tacrine FragmentNeurochemical BiomarkersPharmaceutical ChemistryMolecular PharmacologyAlzheimer's Disease +19

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

J Jerábek, Elisa Uliassi, Laura Guidotti, +11

European Journal of Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseMedicineTacrine-resveratrol Fused HybridsNeurochemical Biomarkers +3

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

Katarina Chalupova, Jan Korábečný, Manuela Bartolini, +32

European Journal of Medicinal Chemistry

NeuropeptidesDrug TargetBiochemistryFunctional SelectivityMedicine +9

Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

Federica Prati, Elisa Uliassi, María Laura Bolognesi

MedChemComm

Promising Therapeutic ApproachNeurodegenerative DiseasesDrug RepositioningAlzheimer's DiseaseDrug Target +13

Toward the Development of Dual‐Targeted Glyceraldehyde‐3‐phosphate Dehydrogenase/Trypanothione Reductase Inhibitors against <i>Trypanosoma brucei</i> and <i>Trypanosoma cruzi</i>

Federica Belluti, Elisa Uliassi, Giacomo Veronesi, +9

ChemMedChem

Structure-Based Design of 3-(4-Aryl-1<i>H</i>-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y₁₄ Receptor Antagonists

Anna Junker, R. Balasubramanian, Antonella Ciancetta, +9

Journal of Medicinal Chemistry

Molecular DockingMolecular PharmacologyMedicinal ChemistryComputational PipelineDrug Target +12

From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer’s Disease?

María Laura Bolognesi, Annachiara Gandini, Federica Prati, +1

Journal of Medicinal Chemistry

Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase ( Tb GAPDH) and Trypanosoma cruzi trypanothione reductase ( Tc TR) and display trypanocidal activity

Elisa Uliassi, Giulia Fiorani, R. Luise Krauth‐Siegel, +17

European Journal of Medicinal Chemistry

Tc TrTb GapdhBiochemistryAntiparasitic AgentMedicine +7

PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease

Melissa Guardigni, Letizia Pruccoli, Alan Santini, +12

ACS Chemical Neuroscience