Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist

Shigeki Hibi, Koshi Ueno, Satoshi Nagato, +6

Journal of Medicinal Chemistry

Synaptic TransmissionPyridone RingNeurotransmitterReceptor AntagonistPharmacotherapy +19

Stereochemistry of palytoxin. Part 4. Complete structure

J. K., William J. Christ, Jennifer M. Finan, +8

Journal of the American Chemical Society

Chemical MeasurementBioorganic ChemistryEngineeringBiochemistryComplete Structure +13

Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium.

Yasuhiro Funahashi, Naoko Hata Sugi, Taro Semba, +15

PubMed

PharmacotherapyCellular PhysiologyTumor BiologyMolecular PharmacologyAngiogenesis +18

Discovery of (1<i>R</i>,2<i>S</i>)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-<i>N</i>-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist

Yu Yoshida, Yoshimitsu Naoe, Taro Terauchi, +10

Journal of Medicinal Chemistry

PharmacotherapyChemical BiologyExperimental PharmacologyPharmaceutical ChemistryMolecular Pharmacology +17

Chiral synthesis of (+)-eburnamine, (–)-eburnamenine, and (–)-eburnamonine

Seiichi Takano, Masahiro Yonaga, Masamichi Morimoto, +1

Journal of the Chemical Society Perkin Transactions 1

Diversity Oriented SynthesisBioorganic ChemistryEngineeringBiochemistryNatural Sciences +10

Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum

Toshiaki Kume, Naoki Asai, Hiroyuki Nishikawa, +14

Proceedings of the National Academy of Sciences

Stereochemistry of palytoxin. Part 2. C1-C6, C47-C74, and C77-C83 segments

S. S. Ko, Jennifer M. Finan, Masahiro Yonaga, +3

Journal of the American Chemical Society

Pharmaceutical ScienceBioorganic ChemistryEngineeringC77-c83 SegmentsChemical Analysis +15

Palladium-Catalyzed Direct Hydroxymethylation of Aryl Halides and Triflates with Potassium Acetoxymethyltrifluoroborate

Norio Murai, Masahiro Yonaga, Keigo Tanaka

Organic Letters

One-Pot Primary Aminomethylation of Aryl and Heteroaryl Halides with Sodium Phthalimidomethyltrifluoroborate

Norio Murai, Masayuki Miyano, Masahiro Yonaga, +1

Organic Letters

Suzuki–miyaura Cross-coupling ReactionsCross-coupling ReactionHeteroaryl HalidesEngineeringAlkene Metathesis +9

Synthesis and Structure–Activity Relationships of Pyrazolo[1,5-<i>a</i>]pyridine Derivatives: Potent and Orally Active Antagonists of Corticotropin-Releasing Factor 1 Receptor

Y. Takahashi, Shigeki Hibi, Yorihisa Hoshino, +6

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +13