Yoshimitsu Naoe

Discovery of (1<i>R</i>,2<i>S</i>)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-<i>N</i>-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist

Yu Yoshida, Yoshimitsu Naoe, Taro Terauchi et al. · Journal of Medicinal Chemistry · 2015 · 84 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A convenient synthesis of acyclic conjugated enediynes

Masayuki Shibuya, Yasuhiro Sakai, Yoshimitsu Naoe · Tetrahedron Letters · 1995 · 28 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

pH dependent cycloaromatization of enediyne model compounds via enyne-allene intermediates

Yoshimitsu Naoe, Junya Kikuishi, Katsuya Ishigaki et al. · Tetrahedron Letters · 1995 · 28 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

Cycloaromatization of enediyne model compounds via a reaction cascade triggered by hydrolysis of the α-alkynylmalonates

Masayuki Shibuya, Masakazu Wakayama, Yoshimitsu Naoe et al. · Tetrahedron Letters · 1996 · 24 citations

Natural Sciences, Chemistry, Catalysis +6

Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists

Yu Yoshida, Taro Terauchi, Yoshimitsu Naoe et al. · Bioorganic & Medicinal Chemistry · 2014 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15