Concepedia

Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists

Yu Yoshida, Taro Terauchi, Yoshimitsu Naoe, Yuji Kazuta, Fumihiro Ozaki, Carsten T. Beuckmann, Makoto Nakagawa, Michiyuki Suzuki, Ikuo Kushida, Osamu Takenaka,

Bioorganic & Medicinal Chemistry · 2014 · 23 citations · 25 references

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References

25

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

Luı́s de Lecea, Thomas S. Kilduff, Christelle Peyron et al. · Proceedings of the National Academy of Sciences · 1998 · 3.9K citations

, , +15

Narcolepsy in orexin Knockout Mice

Richard M. Chemelli, Jon T. Willie, Christopher M. Sinton et al. · Cell · 1999 · 3.1K citations · Full text

, , +12

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

Christelle Peyron, Juliette Faraco, William M. Rogers et al. · Nature Medicine · 2000 · 2.1K citations

, , +13

Reduced Number of Hypocretin Neurons in Human Narcolepsy

Thomas C. Thannickal, Robert Y. Moore, Robert Nienhuis et al. · Neuron · 2000 · 2.1K citations · Full text

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Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice

Jon T. Willie, Richard M. Chemelli, Christopher M. Sinton et al. · Neuron · 2003 · 647 citations · Full text

, , +12