SILYBIN INACTIVATES CYTOCHROMES P450 3A4 AND 2C9 AND INHIBITS MAJOR HEPATIC GLUCURONOSYLTRANSFERASES

Chitra Sridar, Theunis C. Goosen, Ute M. Kent, +2

Drug Metabolism and Disposition

The Endocannabinoid Anandamide Is a Substrate for the Human Polymorphic Cytochrome P450 2D6

Natasha T. Snider, Matthew J. Sikora, Chitra Sridar, +3

Journal of Pharmacology and Experimental Therapeutics

Effect of Tamoxifen on the Enzymatic Activity of Human Cytochrome CYP2B6

Chitra Sridar, Ute M. Kent, L. Notley, +2

Journal of Pharmacology and Experimental Therapeutics

Polymorphic Variants of Cytochrome P450 2B6 (CYP2B6.4–CYP2B6.9) Exhibit Altered Rates of Metabolism for Bupropion and Efavirenz: A Charge-Reversal Mutation in the K139E Variant (CYP2B6.8) Impairs Formation of a Functional Cytochrome P450-Reductase Complex

Haoming Zhang, Chitra Sridar, Cesar Kenaan, +3

Journal of Pharmacology and Experimental Therapeutics

Anandamide Oxidation by Wild-Type and Polymorphically Expressed CYP2B6 and CYP2D6

Chitra Sridar, Natasha T. Snider, Paul F. Hollenberg

Drug Metabolism and Disposition

Bioactivation of the Cancer Chemopreventive Agent Tamoxifen to Quinone Methides by Cytochrome P4502B6 and Identification of the Modified Residue on the Apoprotein

Chitra Sridar, Jaime D’Agostino, Paul F. Hollenberg

Drug Metabolism and Disposition

THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION

Namandjé N. Bumpus, Chitra Sridar, Ute M. Kent, +1

Drug Metabolism and Disposition

The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation

Yasushi Yoshigae, Chitra Sridar, Ute M. Kent, +1

Drug Metabolism and Disposition

Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts

Chitra Sridar, Cesar Kenaan, Paul F. Hollenberg

Drug Metabolism and Disposition

Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches

Chitra Sridar, Imad Hanna, Paul F. Hollenberg

Xenobiotica