Cesar Kenaan

Polymorphic Variants of Cytochrome P450 2B6 (CYP2B6.4–CYP2B6.9) Exhibit Altered Rates of Metabolism for Bupropion and Efavirenz: A Charge-Reversal Mutation in the K139E Variant (CYP2B6.8) Impairs Formation of a Functional Cytochrome P450-Reductase Complex

Haoming Zhang, Chitra Sridar, Cesar Kenaan et al. · Journal of Pharmacology and Experimental Therapeutics · 2011 · 63 citations · Full text

Identification of the Residue in Human CYP3A4 That Is Covalently Modified by Bergamottin and the Reactive Intermediate That Contributes to the Grapefruit Juice Effect

Hsia-lien Lin, Cesar Kenaan, Paul F. Hollenberg · Drug Metabolism and Disposition · 2012 · 61 citations · Full text

Uncovering the Role of Hydrophobic Residues in Cytochrome P450−Cytochrome P450 Reductase Interactions

Cesar Kenaan, Haoming Zhang, Erin V. Shea et al. · Biochemistry · 2011 · 45 citations · Full text

Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the Introduction of a de Novo Disulfide Bond into Cytochrome P450 2B1

Haoming Zhang, Cesar Kenaan, Djemel Hamdane et al. · Journal of Biological Chemistry · 2009 · 33 citations · Full text

Conformational Dynamics, Protein Assembly, Biomolecular Structure Prediction +17

Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts

Chitra Sridar, Cesar Kenaan, Paul F. Hollenberg · Drug Metabolism and Disposition · 2012 · 27 citations · Full text