Michael Ranes

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma et al. · Nature Communications · 2018 · 435 citations · Full text

CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

Reyes Gonzalez-Exposito, Maria Semiannikova, B Griffiths et al. · Journal for ImmunoTherapy of Cancer · 2019 · 110 citations · Full text

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease

Yuming Wang, Probir Chakravarty, Michael Ranes et al. · Proceedings of the National Academy of Sciences · 2014 · 109 citations · Full text

Genetics, Cockayne Syndrome, Disease Gene Identification +18

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling

Laura Mariotti, Catherine M. Templeton, Michael Ranes et al. · Molecular Cell · 2016 · 101 citations · Full text

Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation

Michael Ranes, Mariola Zaleska, Saira Sakalas et al. · Molecular Cell · 2021 · 79 citations · Full text