Zachary T. McEachin

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

Christopher J. Holler, Georgia Taylor, Zachary T. McEachin et al. · Molecular Neurodegeneration · 2016 · 104 citations · Full text

Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36

Zachary T. McEachin, Tania F. Gendron, Nisha Raj et al. · Neuron · 2020 · 72 citations · Full text

Autoimmune Disease, Protein Folding, Medicine +7

A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

Marcela K. Preininger, Rajneesh Jha, Joshua T. Maxwell et al. · Disease Models & Mechanisms · 2016 · 64 citations · Full text

Cardiac Muscle, Heart Failure, Human Pluripotent Stem +19

5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer’s disease

Janise N. Kuehner, Junyu Chen, Emily C. Bruggeman et al. · Cell Reports · 2021 · 57 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Developmental Biology +11

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

Nisha Raj, Zachary T. McEachin, William Harousseau et al. · Cell Reports · 2021 · 55 citations · Full text