Ruth E. Gimeno

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

Tamer Coşkun, Kyle W. Sloop, Corina Loghin et al. · Molecular Metabolism · 2018 · 822 citations · Full text

Medicine, Endocrinology, Pharmacology +17

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

Juan P. Frías, Michael A. Nauck, Joanna Van et al. · The Lancet · 2018 · 799 citations

Medicine, Endocrinology, Pharmacology +17

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages

James A. Timmons, Kristian Wennmalm, Ola Larsson et al. · Proceedings of the National Academy of Sciences · 2007 · 726 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Paul J. Emmerson, Feng Wang, Yong Du et al. · Nature Medicine · 2017 · 650 citations

Life Sciences, Biochemistry, Cell Biology +7

Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis

Ruth E. Gimeno, Marlene Dembski, Xun Weng et al. · Diabetes · 1997 · 480 citations · Full text

Life Sciences, Molecular Biology, Physiology +16