Beth Williamson

Induction of Influx and Efflux Transporters and Cytochrome P450 3A4 in Primary Human Hepatocytes by Rifampin, Rifabutin, and Rifapentine

Beth Williamson, Kelly E. Dooley, Yuan Zhang et al. · Antimicrobial Agents and Chemotherapy · 2013 · 134 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Machine Learning Models for Human <i>In Vivo</i> Pharmacokinetic Parameters with In-House Validation

Filip Miljković, Anton Martinsson, Olga Obrezanova et al. · Molecular Pharmaceutics · 2021 · 91 citations

Pharmacy, Pharmacokinetics, Pharmacology +12

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-<i>a</i>]pyridin-6-yl)amino]-9-(tetrahydro-2<i>H</i>-pyran-4-yl)-7,9-dihydro-8<i>H</i>-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Frederick W. Goldberg, M. Raymond V. Finlay, Attilla Ting et al. · Journal of Medicinal Chemistry · 2019 · 79 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Prediction of In Vivo Pharmacokinetic Parameters and Time–Exposure Curves in Rats Using Machine Learning from the Chemical Structure

Olga Obrezanova, Anton Martinsson, Samar Mahmoud et al. · Molecular Pharmaceutics · 2022 · 76 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +13

Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance

Beth Williamson, Stephanie Harlfinger, Dermot F. McGinnity · Drug Metabolism and Disposition · 2020 · 43 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17