Robert Gustafsson

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Helge Gad, Tobias Koolmeister, Ann‐Sofie Jemth et al. · Nature · 2014 · 525 citations

Tumor Biology, Dntp Pool, Mth1 Inhibition +8

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

Megan Carter, Ann‐Sofie Jemth, Anna Hagenkort et al. · Nature Communications · 2015 · 113 citations · Full text

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

Robert Gustafsson, Ann‐Sofie Jemth, Nina Gustafsson et al. · Cancer Research · 2016 · 94 citations

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Nadilly Bonagas, Nina Gustafsson, Martin Henriksson et al. · Nature Cancer · 2022 · 94 citations · Full text

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Lars Bräutigam, Linda Pudelko, Ann‐Sofie Jemth et al. · Cancer Research · 2016 · 60 citations