Tod Steinfeld

A Novel Multivalent Ligand That Bridges the Allosteric and Orthosteric Binding Sites of the M2 Muscarinic Receptor

Tod Steinfeld, Mathai Mammen, Jacqueline A.M. Smith et al. · Molecular Pharmacology · 2007 · 93 citations

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents

Paul S. Humphries, Ross Bersot, John Kincaid et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 73 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Science +10

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents

Paul S. Humphries, Ross Bersot, John Kincaid et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 49 citations

Medicinal Chemistry, Biochemistry, Medicine +8

THRX-198321 Is a Bifunctional Muscarinic Receptor Antagonist and β2-Adrenoceptor Agonist (MABA) That Binds in a Bimodal and Multivalent Manner

Tod Steinfeld, Adam D. Hughes, Uwe Klein et al. · Molecular Pharmacology · 2010 · 42 citations

Discovery of (<i>R</i>)-1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1′-Biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and β₂ Agonist (MABA) for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)

Adam D. Hughes, Yan Chen, Sharath S. Hegde et al. · Journal of Medicinal Chemistry · 2015 · 34 citations · Full text

Linker Motif, Lung Inflammation, Pharmacotherapy +16