Noncovalent Synthesis: Using Physical-Organic Chemistry To Make Aggregates

George M. Whitesides, Eric E. Simanek, John P. Mathias, +4

Accounts of Chemical Research

Noncovalent SynthesisChemical EngineeringExperimental SynthesisEngineeringChemical Analysis +8

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Noe B. Mercado, Roland Zahn, Frank Wegmann, +65

Nature

VaccinationVaccine DevelopmentRhesus MacaquesImmunologyMedicine +1

Estimating the Entropic Cost of Self-Assembly of Multiparticle Hydrogen-Bonded Aggregates Based on the Cyanuric Acid·Melamine Lattice

Mathai Mammen, Eugene I. Shakhnovich, J. M. Deutch, +1

The Journal of Organic Chemistry

Conformational EntropyFree EnergySupramolecular AssemblyEngineeringMolecular Self-assembly +25

Polyacrylamides Bearing Pendant α-Sialoside Groups Strongly Inhibit Agglutination of Erythrocytes by Influenza Virus:  The Strong Inhibition Reflects Enhanced Binding through Cooperative Polyvalent Interactions

George B. Sigal, Mathai Mammen, Georg Dahmann, +1

Journal of the American Chemical Society

EngineeringAntiviral CompoundMedicinePolymer ScienceImmunology +12

Generation and<i>in Situ</i>Evaluation of Libraries of Poly(acrylic acid) Presenting Sialosides as Side Chains as Polyvalent Inhibitors of Influenza-Mediated Hemagglutination

Seok Ki Choi, Mathai Mammen, George M. Whitesides

Journal of the American Chemical Society

Pharmaceutical ScienceMacromolecular ChemistryEngineeringMicroscale MethodPharmaceutical Chemistry +20

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

Mathai Mammen, Seok Ki Choi, George M. Whitesides

Angewandte Chemie International Edition

Polyvalent InteractionsMolecular BiologyMonovalent InteractionsChemical BiologyMedicinal Chemistry +14

Telavancin Disrupts the Functional Integrity of the Bacterial Membrane through Targeted Interaction with the Cell Wall Precursor Lipid II

Christopher S. Lunde, Stephanie R. Hartouni, James W. Janc, +3

Antimicrobial Agents and Chemotherapy

Using Electrospray Ionization FTICR Mass Spectrometry To Study Competitive Binding of Inhibitors to Carbonic Anhydrase

Xueheng Cheng, Ruidan Chen, James E. Bruce, +9

Journal of the American Chemical Society

Chemical AnalysisBiological Mass SpectrometryAltmetric Attention ScoreChemistryChemical Biology +18

Using a Convenient, Quantitative Model for Torsional Entropy To Establish Qualitative Trends for Molecular Processes That Restrict Conformational Freedom

Mathai Mammen, Eugene I. Shakhnovich, George M. Whitesides

The Journal of Organic Chemistry

Conformational EntropyEngineeringQualitative TrendsComputational ChemistryChemistry +15

A Novel Multivalent Ligand That Bridges the Allosteric and Orthosteric Binding Sites of the M2 Muscarinic Receptor

Tod Steinfeld, Mathai Mammen, Jacqueline A.M. Smith, +2

Molecular Pharmacology