Swathi Sujatha-Bhaskar

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Snahel Patel, Joshua D. Webster, Eugene Varfolomeev et al. · Cell Death and Differentiation · 2019 · 146 citations · Full text

Medicine, Cancer Biology, Oncology +9

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

Emily J. Hanan, Marie-Gabrielle Braun, Robert A. Heald et al. · Journal of Medicinal Chemistry · 2022 · 134 citations · Full text

Medicine, Oncology, Pharmacology +14

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Hans D. Brightbill, Eric Suto, Nicole Blaquière et al. · Nature Communications · 2018 · 128 citations · Full text

Medicine, Immunology, Pharmacology +17

Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Christopher McBride, Lynnie Trzoss, Davide Povero et al. · Journal of Medicinal Chemistry · 2022 · 73 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

Georgette M. Castanedo, Nicole Blaquière, Maureen H. Beresini et al. · Journal of Medicinal Chemistry · 2016 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17