Hiroshi Maegawa

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa et al. · Nature Genetics · 2008 · 766 citations

Genetic Determinant, Autoimmune Disease, Genetics +7

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

Donald A. McClain, Hiroshi Maegawa, J Lee et al. · Journal of Biological Chemistry · 1987 · 405 citations · Full text

Insulin Signaling, Receptor Tyrosine Kinase, Endocytic Pathway +21

Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB

Toshiyuki Obata, Michael B. Yaffe, Germán Leparc et al. · Journal of Biological Chemistry · 2000 · 387 citations · Full text

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition

Issei Tomita, Shinji Kume, Sho Sugahara et al. · Cell Metabolism · 2020 · 337 citations · Full text

Renal Function, Signal Transduction, Medicine +7

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

Atsuko Tagawa, Mako Yasuda, Shinji Kume et al. · Diabetes · 2015 · 301 citations