Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

Shinji Kume, Takashi Uzu, Kihachiro Horiike, +7

Journal of Clinical Investigation

MitophagyMitochondrial DysfunctionCell DeathMitochondrial AutophagyCaloric Restriction +15

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

Munehiro Kitada, Shinji Kume, Noriko Imaizumi, +1

Diabetes

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition

Issei Tomita, Shinji Kume, Sho Sugahara, +12

Cell Metabolism

Renal FunctionSignal TransductionMedicineChronic Kidney DiseaseDiabetes +5

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

Atsuko Tagawa, Mako Yasuda, Shinji Kume, +15

Diabetes

Role of Altered Renal Lipid Metabolism in the Development of Renal Injury Induced by a High-Fat Diet

Shinji Kume, Takashi Uzu, Shin‐ichi Araki, +10

Journal of the American Society of Nephrology

NutritionMetabolic DisorderHigh-fat DietObesityMetabolic Syndrome +17

Structural and functional changes in the kidneys of high-fat diet-induced obese mice

Naoko Deji, Shinji Kume, Shin‐ichi Araki, +9

American Journal of Physiology-Renal Physiology

NutritionMetabolic DisorderRenal PathologyFunctional ChangesCaloric Restriction +20

SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation

Shinji Kume, Masakazu Haneda, Keizo Kanasaki, +8

Journal of Biological Chemistry

Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions

Kosuke Yamahara, Shinji Kume, Daisuke Koya, +11

Journal of the American Society of Nephrology

MitophagyRenal PathologyImmunologyCell DeathObesity +21

Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis

Yuki Tanaka, Shinji Kume, Shin‐ichi Araki, +9

Kidney International

Molecular PharmacologyMolecular PhysiologyMedicinePhysiologyRenal Lipolysis +9

Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation

Shinji Kume, Masakazu Haneda, Keizo Kanasaki, +7

Free Radical Biology and Medicine

Cell RegulationApoptosisP53 DeacetylationCell DeathTumor Suppressor +5